期刊
MOLECULAR THERAPY-NUCLEIC ACIDS
卷 10, 期 -, 页码 269-276出版社
CELL PRESS
DOI: 10.1016/j.omtn.2017.12.011
关键词
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资金
- National Natural Science Foundation of China [91632114, 31571039, 81771150, 81761138043, 51627807, 31721002]
- National Program for Support of Top-Notch Young Professionals and Academic Frontier Youth Team of Huazhong University of Science and Technology
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13016]
- independent innovation research fund of Huazhong University of Science and Technology [2014TS073]
Long non-coding RNA (lncRNA) is a kind of non-coding RNA (ncRNA), with a length of 200 nt to 100 kb, that lacks a significant open reading frame (ORF) encoding a protein. lncRNAs are widely implicated in various physiological and pathological processes, such as epigenetic regulation, cell cycle regulation, cell differentiation regulation, cancer, and neurodegenerative diseases, through their interactions with chromatin, protein, and other RNAs. Numerous studies have suggested that lncRNAs are closely linked with the occurrence and development of a variety of diseases, especially neurodegenerative diseases, of which the etiologies are complicated and the underlying mechanisms remain elusive. Determining the roles of lncRNA in the pathogenesis of neurodegenerative diseases will not only deepen understanding of the physiological and pathological processes that occur in those diseases but also provide new ideas and solutions for their diagnosis and prevention. This review aims to highlight the progress of lncRNA research in the pathological and behavioral changes of neurodegenerative diseases. Specifically, we focus on how lncRNA dysfunctions are involved in the pathogenesis of Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
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