期刊
GENES
卷 9, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/genes9020067
关键词
cancer progression; tumor suppressor genes; oncojanus genes; oncogene; RhoB; Rho GTPases
资金
- NCI [R00-CA181352, U54-CA210173]
- Susan G. Komen Foundation [CCR17483484]
- Breast Cancer Research Foundation
- JKTG foundation
Although Rho GTPases RhoA, RhoB, and RhoC share more than 85% amino acid sequence identity, they play very distinct roles in tumor progression. RhoA and RhoC have been suggested in many studies to contribute positively to tumor development, but the role of RhoB in cancer remains elusive. RhoB contains a unique C-terminal region that undergoes specific post-translational modifications affecting its localization and function. In contrast to RhoA and RhoC, RhoB not only localizes at the plasma membrane, but also on endosomes, multivesicular bodies and has even been identified in the nucleus. These unique features are what contribute to the diversity and potentially opposing functions of RhoB in the tumor microenvironment. Here, we discuss the dualistic role that RhoB plays as both an oncogene and tumor suppressor in the context of cancer development and progression.
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