期刊
FRONTIERS IN PHARMACOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2017.00997
关键词
cystic fibrosis; CFTR interactome; protein-protein interactions; proteomics; interactome mapping
资金
- Cystic Fibrosis Canada [2847]
- Canadian Cancer Society Research Institute [703889]
- Genome Canada via Ontario Genomics [9427, 9428]
- Ontario Research Fund [ORF/DIG-501411, RE08-009]
- Consortium Quebecois sur la Decouverte du Medicament
- Brain Canada
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel found in secretory epithelia with a plethora of known interacting proteins. Mutations in the CFTR gene cause cystic fibrosis (CF), a disease that leads to progressive respiratory illness and other complications of phenotypic variance resulting from perturbations of this protein interaction network. Studying the collection of CFTR interacting proteins and the differences between the interactomes of mutant and wild type CFTR provides insight into the molecular machinery of the disease and highlights possible therapeutic targets. This mini review focuses on functional genomics and proteomics approaches used for systematic, high-throughput identification of CFTR-interacting proteins to provide comprehensive insight into CFTR regulation and function.
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