期刊
JOURNAL OF PARKINSONS DISEASE
卷 1, 期 1, 页码 19-33出版社
IOS PRESS
DOI: 10.3233/JPD-2011-11023
关键词
substantia nigra; dopamine; C57/BL mouse; grid test; hydropyridine; open field; rotarod
资金
- USAM-RMC NETRP Program [NS41799, W81XWH-05-1-0580]
Among the most widely used models of Parkinson's disease (PD) are those that employ toxins, especially 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Depending on the protocol used, MPTP yields large variations in nigral cell loss, striatal dopamine loss and behavioral deficits. Motor deficits do not fully replicate those seen in PD. Nonetheless, MPTP mouse models mimic many aspects of the disease and are therefore important tools for understanding PD. In this review, we will discuss the ability of MPTP mouse models to replicate the pathophysiology of PD, the mechanisms of MPTP-induced neurotoxicity, strain differences in susceptibility to MPTP, and the models' roles in testing therapeutic approaches.
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