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A Phase II, double-blind, placebo-controlled, ascending-dose study of eritoran (E5564), a lipid a antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
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ANESTHESIA AND ANALGESIA (2007)
MicroRNA-155 is induced during the macrophage inflammatory response
Ryan M. O'Connell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Michelle L. Block et al.
NATURE REVIEWS NEUROSCIENCE (2007)
Toll-like receptor 2 signaling in response to brain injury: An innate bridge to neuroinflammation
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JOURNAL OF NEUROSCIENCE (2006)
Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra
Carina Cintia Ferrari et al.
NEUROBIOLOGY OF DISEASE (2006)
Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
Melissa K. McCoy et al.
JOURNAL OF NEUROSCIENCE (2006)
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
Konstantin D. Taganov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Tumor necrosis factor-α induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
TLR1- and TLR6-independent recognition of bacterial lipopeptides
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling
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MOLECULAR PHARMACOLOGY (2006)
Binding specificity of Toll-like receptor cytoplasmic domains
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EUROPEAN JOURNAL OF IMMUNOLOGY (2006)
Pathogen recognition and innate immunity
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CELL (2006)
BMS-345541 targets inhibitor of κB kinase and induces apoptosis in melanoma:: Involvement of nuclear factor κB and mitochondria pathways
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CLINICAL CANCER RESEARCH (2006)
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
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NEUROBIOLOGY OF DISEASE (2006)
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide
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MOLECULAR AND CELLULAR BIOLOGY (2006)
In vivo imaging of microglial activation with [C-11](R)-PK11195 PET in progressive supranuclear palsy
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MOVEMENT DISORDERS (2006)
MAP kinase kinase kinases and innate immunity
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TRENDS IN IMMUNOLOGY (2006)
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop
Ian G. McKeith
JOURNAL OF ALZHEIMERS DISEASE (2006)
Epidemiology of Parkinson's disease
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LANCET NEUROLOGY (2006)
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Intravesicular localization and exocytosis of α-synuclein and its aggregates
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JOURNAL OF NEUROSCIENCE (2005)
Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury
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JOURNAL OF IMMUNOLOGY (2005)
ATP mediates rapid microglial response to local brain injury in vivo
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NATURE NEUROSCIENCE (2005)
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
A Nimmerjahn et al.
SCIENCE (2005)
The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Aggregated α-synuclein activates microglia:: a process leading to disease progression in Parkinson's disease
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FASEB JOURNAL (2005)
Microglial activation and dopamine terminal loss in early Parkinson's disease
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ANNALS OF NEUROLOGY (2005)
Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6
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INFECTION AND IMMUNITY (2004)
In vivo imaging of microglial activation with [11C](R)-PK 11195 PET in corticobasal degeneration
A Gerhard et al.
MOVEMENT DISORDERS (2004)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
A microRNA array reveals extensive regulation of microRNAs during brain development
AM Krichevsky et al.
RNA (2003)
Importance of extra- and intracellular domains of TLR1 and TLR2 in NFκB signaling
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JOURNAL OF CELL BIOLOGY (2003)
Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
HL Chen et al.
ARCHIVES OF NEUROLOGY (2003)
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Part II:: α-synuclein and its molecular pathophysiological role in neurodegenerative disease
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NEUROPHARMACOLOGY (2003)
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression - A randomized controlled trial
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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)
Staging of brain pathology related to sporadic Parkinson's disease
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NEUROBIOLOGY OF AGING (2003)
The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
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NEURON (2003)
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction
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NATURE IMMUNOLOGY (2003)
Cutting edge:: A novel toll/IL-1 receptor Domain containing adapter that preferentially activates the IFN-β promoter in the toll-like receptor signaling
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JOURNAL OF IMMUNOLOGY (2002)
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
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SCIENCE (2002)
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
T Horng et al.
NATURE (2002)
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
M Yamamoto et al.
NATURE (2002)
SOCS-1 participates in negative regulation of LPS responses
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IMMUNITY (2002)
Annular α-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes
TT Ding et al.
BIOCHEMISTRY (2002)
Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
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JOURNAL OF IMMUNOLOGY (2002)
Dopamine-dependent neurotoxicity of α-synuclein:: A mechanism for selective neurodegeneration in Parkinson disease
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NATURE MEDICINE (2002)
Occupational and environmental risk factors for Parkinson's disease
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PARKINSONISM & RELATED DISORDERS (2002)
Vesicle permeabilization by protofibrillar α-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism
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BIOCHEMISTRY (2002)
Molecular crowding accelerates fibrillization of α-synuclein:: Could an increase in the cytoplasmic protein concentration induce Parkinson's disease?
MD Shtilerman et al.
BIOCHEMISTRY (2002)
α-Synuclein is phosphorylated in synucleinopathy lesions
H Fujiwara et al.
NATURE CELL BIOLOGY (2002)
Negative regulation of toll-like receptor-mediated signaling by Tollip
GL Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
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SCIENCE (2001)
Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins
RJ Perrin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Vesicle permeabilization by protofibrillar α-synuclein:: Implications for the pathogenesis and treatment of Parkinson's disease
MJ Volles et al.
BIOCHEMISTRY (2001)
Discrimination of bacterial lipoproteins by Toll-like receptor 6
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INTERNATIONAL IMMUNOLOGY (2001)
Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2:: Role of N-terminal hydrophobic portion in its multiple functions
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JOURNAL OF IMMUNOLOGY (2001)
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and-2
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MOLECULAR AND CELLULAR NEUROSCIENCE (2000)
Cutting edge:: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
O Takeuchi et al.
JOURNAL OF IMMUNOLOGY (2000)
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
YW Xu et al.
NATURE (2000)
Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
KA Conway et al.
BIOCHEMISTRY (2000)
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