期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2018.00238
关键词
Drosophila melanogaster; cryptochrome; F-actin; phototransduction; activity rhythms
资金
- German Research Foundation (DFG) [Fo207/10-3, SFB1047, INST 93/784-1]
- European Community (6th Framework Project EUCLOCK) [018741]
- Fondazione Cariparo (Progetti di Eccellenza)
- Epigenomics Flagship Project 2012-EPIGEN (Consiglio Nazionale delle Ricerche-CNR)
- Seventh Framework Programme (INsecTIME Marie Curie Initial Training Network) [PITN-GA-2012-316790]
- Hanns-Seidel-Foundation excellence grant - BMBF (Bundesministerium fur Bildung und Forschung)
- Hanns-Seidel-Foundation excellence grant - German Ministry for Education
- Hanns-Seidel-Foundation excellence grant - DFG Research fellowship
- German Excellence Initiative
Cryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of circadian rhythmicity. Moreover, CRYs are sensing magnetic fields in insects as well as in humans. Here, we show that in the fruit fly Drosophila melanogaster CRY plays a light-independent role as assembling protein in the rhabdomeres of the compound eyes. CRY interacts with actin and appears to increase light sensitivity of the eyes by keeping the signalplex of the phototransduction cascade close to the membrane. By this way, CRY also enhances light-responses of the circadian clock.
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