期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2018.00211
关键词
SOX11; transcription factor phosphorylation; subcellular localization; neurogenesis; cancer; intellectual disability
资金
- German Research Foundation [LI 858/6-3, LI 858/9-1, INST 410/45-1]
- University Hospital Erlangen (IZKF) [E12, E16, E21]
- Deutsche Forschungsgemeinschaft (DFG) [GRK2162/1]
- Helmholtz-Gemeinschaft Grant iMed-Helmholtz Initiative on Personalized Medicine
- Austrian Science Fund (FWF) [E12] Funding Source: Austrian Science Fund (FWF)
SOX11 is a key Transcription Factor (TF) in the regulation of embryonic and adult neurogenesis, whose mutation has recently been linked to an intellectual disability syndrome in humans. SOX11's transient activity during neurogenesis is critical to ensure the precise execution of the neurogenic program. Here, we report that SOX11 displays differential subcellular localizations during the course of neurogenesis. Western-Blot analysis of embryonic mouse brain lysates indicated that SOX11 is post-translationally modified by phosphorylation. Using Mass Spectrometry, we found 10 serine residues in the SOX11 protein that are putatively phosphorylated. Systematic analysis of phospho-mutant SOX11 resulted in the identification of the S30 residue, whose phosphorylation promotes nuclear over cytoplasmic localization of SOX11. Collectively, these findings uncover phosphorylation as a novel layer of regulation of the intellectual disability gene Sox11.
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