期刊
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
卷 24, 期 3, 页码 193-202出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SPV.0000000000000559
关键词
phytoestrogens; isoflavones; lignans; pelvic floor disorders; urinary incontinence; pelvic organ prolapse; fecal incontinence; postmenopausal women
资金
- NICHD NIH HHS [K12 HD001258] Funding Source: Medline
Introduction: Urinary incontinence, pelvic organ prolapse, and fecal incontinence are pelvic floor disorders (PFDs) disproportionately experienced by postmenopausal women. Limited data exist suggesting that phytoestrogens may have an impact on the pathophysiology and symptom of PFDs. Purpose of Review: The aim of the study was to review the current literature addressing the role of phytoestrogens on PFDs, including the pathophysiology, symptom, treatment, and possible prevention. Findings: Qualifying literature spans from 2003 to 2017 and included 14 studies ranging from in vitro, animal, and observational studies to randomized clinical trials. Summary: Although the literature is limited, most studies on phytoestrogens and PFDs support associations with pathophysiologic mechanisms, symptoms, and treatment for urinary incontinence and pelvic organ prolapse, but not fecal incontinence. Less is known regarding the prevention of PFDs with phytoestrogen intake over time. Overall, the potential influence of phytoestrogens on PFDs is not well understood, and more research is needed.
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