期刊
FEBS OPEN BIO
卷 8, 期 3, 页码 449-460出版社
WILEY
DOI: 10.1002/2211-5463.12382
关键词
gastrointestinal tract; hormone; liver regeneration; neural relay; serotonin
资金
- Brain Research Institute, Niigata University
- Grants-in-Aid for Scientific Research [17H06691] Funding Source: KAKEN
The development of therapeutic options to promote hepatic regeneration following severe liver injury is essential. While humoral factors have been reported as mechanisms of liver regeneration, the contributions of interorgan communication to liver regeneration have not been reported. In this study, we examined the effect of a neural relay on liver regeneration via activation of serotonin release from the gastrointestinal (GI) tract. Our results demonstrated that the afferent visceral nerve from the liver activates the efferent vagus nerve from the brain, leading to activation of serotonin release from the GI tract and contributing to liver regeneration. While it is difficult to apply these results directly to human health, we believe that this study may represent a step toward developing essential therapeutics to promote liver regeneration.
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