期刊
FEBS OPEN BIO
卷 8, 期 4, 页码 664-670出版社
WILEY
DOI: 10.1002/2211-5463.12400
关键词
albuminuria; CKD; Inflammation; NF-kappa B; obesity
资金
- JSPS KAKENHI [17K09720]
- Yakult Bio-Science Foundation
- Baxter International
- Chugai Pharmaceutical
- Kyowa Kirin
- Sumitomo Dainippon Pharma
- Otsuka
- Teijin Pharma
- Torii
- Taisho-Toyama
- Boehringer Ingelheim
- Sanofi
- Grants-in-Aid for Scientific Research [17K18257, 17K09720] Funding Source: KAKEN
Obesity is one of risk factors for chronic kidney disease (CKD), but the precise mechanism involved is unclear. This study characterizes the effect of obesity-induced glomerular inflammation, oxidative stress, and albuminuria in obese rats. Glomerular samples were collected from fatty (ZF) and lean (ZL) Zucker rats. After 2 months of feeding, body weight and albuminuria were significantly increased in ZF rats when compared to ZL rats. Expression of the inflammatory markers TNF-alpha and CCR2 was significantly increased in the glomeruli of ZF rats. However, expression of IL-6 mRNA was not increased. Analysis of renal pathology showed no glomerular expansion. As inflammatory and oxidative stress markers are associated with NF-kappa B, we evaluated whether NF-kappa B activation was increased in the glomeruli of mice on a high-fat diet. Immunohistochemistry showed increased NF-kappa B activation in the glomeruli when transgenic mice overexpressing an NF-kappa B-dependent enhanced green fluorescent protein were fed with a high-fat diet. These results suggest that obesity of only 2 months duration can cause albuminuria, due to increased inflammation or oxidative stress, but may not be long enough to develop renal pathological changes.
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