期刊
EMERGING MICROBES & INFECTIONS
卷 7, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1038/s41426-018-0095-0
关键词
-
资金
- National Natural Science Foundation of China [31625002, 31370175, 31570139]
- National Science and Technology Major Project [2018ZX10101004-003-002]
The emerging human fungal pathogen Candida auris has been recognized as a multidrug resistant species and is associated with high mortality This fungus was first described in Japan in 2009 and has been reported in at least 18 countries on five continents In this study, we report the first isolate of C. auris from the bronchoalveolar lavage fluid (BALF) of a hospitalized woman in China Interestingly, this isolate is susceptible to all tested antifungals including amphotericin B, fluconazole, and caspofungin Copper sulfate (CuSO4) also has a potent inhibitory effect on the growth of this fungus Under different culture conditions, C. auris exhibits multiple morphological phenotypes including round-to-ovoid, elongated, and pseudohyphal like forms High concentrations of sodium chloride induce the formation of a pseudohyphal-like form We further demonstrate that C. auris is much less virulent than Candida albicans in both mouse systemic and invertebrate Galleria mellonella models
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据