期刊
CANCER MEDICINE
卷 7, 期 4, 页码 1338-1348出版社
WILEY
DOI: 10.1002/cam4.1344
关键词
High-dose radiation; immune enhancement; low-dose radiation; lung cancer; mouse model
类别
资金
- National Natural Science Foundation of China [81672275]
- Industrial Research and Development Project of Development and Reform Commission of Jilin Province [2017C022]
- Ministry of Science and Technology of China [2016YFC1303800]
- Key Laboratory Construction Project of Science and Technology Department of Jilin Province [20170622011JC]
- Development and Reform Commission of Jilin Province [2014N147]
- Health and Family Planning Commission of Jilin Province, China [2016Q035]
- Youth Fund of the First Hospital of Jilin University
- Youth Fund of National Natural Science [81302380]
Although low-dose radiation (LDR) possesses the two distinct functions of inducing hormesis and adaptive responses, which result in immune enhancement and tumor inhibition, its clinical applications have not yet been elucidated. The major obstacle that hinders the application of LDR in the clinical setting is that the mechanisms underlying induction of tumor inhibition are unclear, and the risks associated with LDR are still unknown. Thus, to overcome this obstacle and elucidate the mechanisms mediating the antitumor effects of LDR, in this study, we established an in vivo lung cancer model to investigate the participation of the immune system in LDR-induced tumor inhibition and validated the pivotal role of the immune system by impairing immunity with high-dose radiation (HDR) of 1 Gy. Additionally, the LDR-induced adaptive response of the immune system was also observed by sequential HDR treatment in this mouse model. We found that LDR-activated T cells and natural killer cells and increased the cytotoxicity of splenocytes and the infiltration of T cells in the tumor tissues. In contrast, when immune function was impaired by HDR pretreatment, LDR could not induce tumor inhibition. However, when LDR was administered before HDR, the immunity could be protected from impairment, and tumor growth could be inhibited to some extent, indicating the induction of the immune adaptive response by LDR. Therefore, we demonstrated that immune enhancement played a key role in LDR-induced tumor inhibition. These findings emphasized the importance of the immune response in tumor radiotherapy and may help promote the application of LDR as a novel approach in clinical practice.
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