期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA
卷 2, 期 1, 页码 343-352出版社
KARGER
DOI: 10.1159/000341782
关键词
Parkinson's disease; Mild cognitive impairment; Education; IQ; Cognitive reserve
资金
- Michael J. Fox Foundation for Parkinson's Research
- Canadian Institutes of Health Research [IAO-90399]
- Michael J. Fox Foundation
- National Parkinson Foundation
- Canadian Institutes of Health Research
- NIH [NS060722, ES019672, AG027771, NS44504-08, P01 NS015655-26A1, R01 PAS-03-092 NIA]
- Pennsylvania Department of Health
- Parkinson Alliance
- Neurologix, Inc.
- co-PI on MCASTL [RFP2010-04]
- Parkinson Support Center of Kentuckiana
- CurePSP
- Noscira
- Allon Therapeutics
- Parkinson Study Group
- Parkinson Society Canada
- NIH
Background/Aims: The role of cognitive reserve in Parkinson's disease (PD)-mild cognitive impairment (MCI) is incompletely understood. Methods: The relationships between PD-MCI, years of education, and estimated premorbid IQ were examined in 119 consecutive non-demented PD patients using logistic regression models. Results: Higher education and IQ were associated with reduced odds of PD-MCI in univariate analysis. In multivariable analysis, a higher IQ was associated with a significantly decreased odds of PD-MCI, but education was not. Conclusion: The association of higher IQ and decreased odds of PD-MCI supports a role for cognitive reserve in PD, but further studies are needed to clarify the interaction of IQ and education and the impact of other contributors such as employment and hobbies. Copyright (C) 2012 S. Karger AG, Basel
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