期刊
BRAIN AND BEHAVIOR
卷 8, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/brb3.941
关键词
circulating miRNAs; diagnosis; Parkinson's disease
资金
- Tianjin Health Bureau [2013KR12]
Objective: To detect the aberrant expression of circulating miRNAs and explore the potential early diagnostic biomarkers in patients with Parkinson's disease (PD). Methods: Plasma samples were collected from 25 treatment-naive PD-diagnosed patients and 25 healthy controls followed by a real-time PCR-based miRNA screening analysis of neuron disease-related miRNAs. Results: A subset of miRNAs with aberrant expression levels in the plasma of PD-diagnosed patients were identified including upregulation of miR-27a and downregulation of let-7a, let-7f, miR-142-3p, and miR-222 with the AUC values more than 0.8 derived from the receiver operating characteristic curves. Conclusions: The high sensitivity and specificity of the circulating miRNAs may enable early diagnosis of PD. The study provides a group of novel miRNA candidates for detecting PD.
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