期刊
BONE & JOINT RESEARCH
卷 7, 期 2, 页码 173-178出版社
BRITISH EDITORIAL SOC BONE JOINT SURGERY
DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1
关键词
Osteoporosis; CKIP-1; Bone formation; BMP pathway
资金
- Research Grants Council of the Hong Kong Special Administrative Region, China [14119115, 14160917, 9054014 N_CityU102/15, T13-402/17-N]
- National Natural Science Foundation of China [81371946, 81430049, 81772322]
- Hong Kong Innovation Technology Commission Funds [ITS/UIM-305]
- Shenzhen Science and Technology Innovation Council of China [JCYJ20150630165236960, JSGG20160229195900623, JCYJ20150402152005636]
- Sanming Project of medicine in Shenzhen [SZSM20150602]
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment.
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