期刊
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
卷 125, 期 2, 页码 163-173出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2018.1443470
关键词
Alloxane; diabetes; Artemisia herba alba; free radicals; oxidative stress
资金
- DG-RSDT grants (Directorate General for Scientific Research and Technological Development at Algerian Ministry of Higher Education and Scientific Research, via the Laboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, University of [PNR/SF 08/2012]
Chronic hyperglycemia and excess reactive oxygen species overproduced in diabetes were associated with oxidative stress, led to continuous injury and functions damage to different organs: eyes, kidneys, neural and cardiovascular system. The present study was undertaken to evaluate the protective effect of Artemisia herba alba (AHA) leaf powder against alloxane-induced oxidative damage in diabetic rats. Rats were randomly divided into four groups: Group I controls received saline solution 9%; Group II was treated with 150 mg alloxane/(kg body weight) administered by intraperitoneal. Rats of Group III have received saline solution and treated with 400 mg AHA/(kg body weight). Animals of Group IV were treated with alloxane and AHA. Alloxane exposure led to increased blood glucose, total cholesterol, triglycerides, malondialdehyde, and a decrease in the antioxidants enzymes activities (catalase, glutathione peroxidase and glutathione-S-transferase). Administration of AHA aqueous extract ameliorated these parameters. These results demonstrate that AHA ameliorates hyperglycemia, hyperlipidemia and oxidative damage in alloxan-induced diabetes in rats.
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