期刊
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES
卷 4, 期 1, 页码 66-69出版社
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/0975-7406.92739
关键词
Bacillus; bacilosarcin A; isocoumarins; Leptogorgia alba; marine bacteria; octocorals; Plasmodium falciparum
资金
- National Secretariat for Science and Technology of Panama (SENACYT) [COL08-061]
- Fogarty International Center's International Cooperative Biodiversity Groups program [TW006634]
Aim: This study was designed for isolating and characterizing antiplasmodial compounds from marine octocoral-associated bacteria. Materials and Methods: The organic extract of the Bacillus sp. was subjected to purification using several chromatography techniques guided by bioassays to yield three isocoumarin derivatives (1-3). Chemical structures of the compounds were elucidated on the basis of HRMS spectra and NMR spectroscopy. The antiplasmodial activity of the isolated compounds was evaluated in vitro against the chloroquine-resistant Plasmodium falciparum strain W2. Results: Isolated compounds were identified as bacilosarcin A (1), AI77-F (2), and AI77-H (3). Bacilosarcin A (1) displayed a low micromolar activity (IC50 = 2.2 mu M) against P. falciparum while compounds 2 and 3 showed no activity. Conclusions: Bacilosarcin A was found to be responsible for the antiplasmodial activity observed in the crude extract obtained from the Bacillus sp.
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