期刊
TOXICOLOGY RESEARCH
卷 7, 期 1, 页码 127-135出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tx00261k
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资金
- National Natural Science Foundation of China
- National Basic Research Program of China (973 Program) [2013CB127106]
- China Postdoctoral Science Foundation [2017M621059]
Studies have shown that aluminum (Al) is the most abundant neurotoxic element on Earth, and is implicated in the pathogenesis of Alzheimer's disease ( AD). However, the mechanisms underlying Al-induced neurotoxicity are still largely elusive. Based on affinity analyses with Al and LC-LTQ-MS, we have found that serum albumin, brain CK-B and 14-3-3 zeta protein have a high affinity for Al3+, and albumin has a much stronger affinity for Al than transferrin. The normal activity of CK-B, and physiological combination of 143-3 zeta with tau can be severely perturbed by Al. We anticipate that our assay will provide a new focus concerning the mechanism underlying Al-induced neurotoxicity, and aid the design of strategies to prevent AD and other human diseases related to Al overload.
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