期刊
PHARMACEUTICALS
卷 5, 期 1, 页码 79-93出版社
MDPI
DOI: 10.3390/ph5010079
关键词
HER2; PET; Zr-89; immunoPET
资金
- DOE Integrated Research Training Program of Excellence in Radiochemistry [DE-SC0002032]
- U.S. Department of Energy (DOE) [DE-SC0002032] Funding Source: U.S. Department of Energy (DOE)
The human epidermal growth factor receptor 2 (HER2/neu) is overexpressed in 20-30% of breast cancers and is associated with tumor growth, angiogenesis, and development of distant metastases. Trastuzumab, an anti-HER2 monoclonal antibody, is used for the treatment of HER2 positive breast cancer and clinical efficacy of this agent is dependent on HER2 expression. Targeted PET imaging of HER2 with radiolabeled trastuzumab may be used to determine HER2 expression levels and guide therapy selection. The purpose of the current study was to evaluate a facile Zr-89-trastuzumab preparation method that can be efficiently applied for clinical grade production. Also, relative HER2 expression levels in orthotopic and metastatic breast cancer models were assessed by PET imaging using the Zr-89-trastuzumab produced by this simpler method.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据