期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 2, 页码 1355-1363出版社
AMER CHEMICAL SOC
DOI: 10.1021/am507798d
关键词
paclitaxel; graphene oxide; PEG; drug delivery
资金
- National Natural Science Foundation of China [21204098, 31100549, 11275050]
- Shanghai Scientific and Technological Innovation Project [11 nm0501100, 11ZR1445900, 14520720100, 14520720700]
- State Key Laboratory of Bioreactor Engineering [2060204]
- Fundamental Research Funds for the Central Universities [222201313010]
Paclitaxel (PTX) is an extensively used potent chemotherapy drug; however, low water solubility, poor bioavailability, and emergence of drug resistance in patients limited its biological application. In this report, we proposed a new drug delivery system for cancer therapy based on graphene oxide (GO), a novel 2D nanomaterial obtained from the oxidation of natural graphite, to improve the utilization rate of PTX. PTX was first connected to biocompatible 6-armed poly(ethylene glycol), followed by covalent introduction into the surface of GO sheets via a facile amidation process under mild conditions, affording the drug delivery system, GO-PEG-PTX (size 50200 nm). GO-PEG nanosized carrier could quickly enter into human lung cancer A549 and human breast cancer MCF-7 cells verified by inverted fluorescence microscope using fluorescein isothiocyanate as probe. This nanocarrier was nontoxic to A549 and MCF-7 cells without linking with PTX. Nevertheless, GO-PEG-PTX showed remarkably high cytotoxicity to A549 and MCF-7 cells in a broad range of concentration of PTX and time compared to free PTX. This kind of nanoscale drug delivery system based on PEGylated GO may find widespread application in biomedicine.
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