期刊
PATHOGENS AND DISEASE
卷 76, 期 1, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femspd/fty004
关键词
Caenorhabditis elegans; Paracoccidioides brasiliensis; Paracoccidioides lutzii; fungal infection model; innate immune response; immunomodulation
资金
- Fundacao de Apoio a Pesquisa do Estado de Sao Paulo [2013/10917-9, 2015/03700-9, 2015/14023-8, 2014/10446-9]
- Rede Nacional de Metodos Alternativos - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [403586/2012-7]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Programa de Apoio ao Desenvolvimento Cientifico da Faculdade de Ciencias Farmaceuticas da UNESP
Paracoccidioidomycosis is a systemic fungal infection affecting mainly Latin American countries that is caused by Paracoccidioides brasiliensis and Paracoccidioides lutzii. During the study of fungal pathogenesis, in vivo studies are crucial to understand the overall mechanisms involving the infection as well as to search for new therapeutic treatments and diagnosis. Caenorhabditis elegans is described as an infection model for different fungi species and a well-characterized organism to study the innate immune response. This study evaluates C. elegans as an infection model for Paracoccidioides spp. It was observed that both species do not cause infection in C. elegans, as occurs with Candida albicans, and one possible explanation is that the irregular size and shape of Paracoccidioides spp. difficult the ingestion of these fungi by the nematode. Besides this difficulty in the infection, we could observe that the simple exposition of C. elegans to Paracoccidioides species was able to trigger a distinct pattern of expression of antimicrobial peptide genes. The expression of cnc-4, nlpl-27 and nlp-31 was superior after the exposure to P. brasiliensis in comparison to P. lutzii (P < 0.05), and these findings demonstrate important differences regarding innate immune response activation caused by the two species of the Paracoccidioides genus.
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