期刊
MULTIPLE SCLEROSIS JOURNAL
卷 24, 期 7, 页码 886-894出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458518777377
关键词
Multiple sclerosis; rehabilitation; exercise therapy; early treatment; window of opportunity
资金
- Tryg
- Danish MS Society
- Knud and Edith Eriksens memorial fund
While early medical treatment has proven effective in MS, early-phase MS rehabilitation has not gained much attention in MS research and clinical practice. Exercise therapy is one of the most promising treatment strategies in MS rehabilitation. Here, we provide a topical review investigating when exercise therapy is initiated in existing MS studies, showing that exercise is initiated at a rather late disease stage, where it predominantly serves as a symptomatic treatment. Recent findings in MS suggest that exercise may have neuroprotective and disease-modifying effects. Such findings along with the findings from medical trials that an early-stage window of opportunity exists leads to the proposal that early exercise therapy should be an increased focus in research and clinical practice for persons with MS. A further perspective relates to other rehabilitation interventions that are also initiated at a later disease stage, as these may also take advantage of an early-phase approach.
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