期刊
MICROMACHINES
卷 9, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/mi9030131
关键词
neural probe; floating implantation; chronic recording; long-term stability; intracortical; PEDOT: PSS; polyimide; silicon probe
类别
资金
- Priority Program SPP 1665 Resolving and Manipulating Neuronal Networks in the Mammalian Brain-From Correlative to Causal Analysis of the DFG (German Research Foundation) [LA 1471/11-2, KR 1844/2-2]
- German Excellence Initiative via the Creative Unit I-See-The Artificial Eye: Chronic Wireless Interface to the Visual Cortex
Bidirectional neural interfaces for multi-channel, high-density recording and electrical stimulation of neural activity in the central nervous system are fundamental tools for neuroscience and medical applications. Especially for clinical use, these electrical interfaces must be stable over several years, which is still a major challenge due to the foreign body response of neural tissue. A feasible solution to reduce this inflammatory response is to enable a free-floating implantation of high-density, silicon-based neural probes to avoid mechanical coupling between the skull and the cortex during brain micromotion. This paper presents our latest development of a reproducible microfabrication process, which allows a monolithic integration of a highly-flexible, polyimide-based cable with a silicon-stiffened neural probe at a high resolution of 1 mu m. For a precise and complete insertion of the free-floating probes into the cortex, a new silicon-based, vacuum-actuated insertion tool is presented, which can be attached to commercially available electrode drives. To reduce the electrode impedance and enable safe and stable microstimulation an additional coating with the electrical conductive polymer PEDOT: PSS is used. The long-term stability of the presented free-floating neural probes is demonstrated in vitro and in vivo. The promising results suggest the feasibility of these neural probes for chronic applications.
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