期刊
MEDICAL SCIENCE MONITOR
卷 24, 期 -, 页码 3184-3192出版社
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.907569
关键词
Angiogenesis Inducing Agents; Antigen Presentation; Antigens, Tumor-Associated, Carbohydrate; Inflammation Mediators
Background: The aim of this study was to evaluate the efficacy, safety, and cost of treatment of the traditional Chinese herb- al medicine, catalpol, in patients following surgical resection for locally advanced colon cancer. Material/Methods: The 345 patients who had undergone surgical resection for locally advanced colon adenocarcinoma, were divided into three groups: a placebo-treated group (n=115); patients treated with an intraperitoneal injection of 10 mg/kg catalpol twice a day for 12 weeks (treatment group) (n=115); patients treated with 5 mg/kg intravenous bevacizumab twice a week for 12 weeks (control group) (n=115). Serum levels of carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA), matrix metalloproteinases-2 (MMP-2), and matrix metalloproteinases-9 (MMP-9) were measured. Patient overall survival (OS), cancer-free survival (CFS), adverse effects, and cost of therapy were evaluated. Statistical analysis included the Wilcoxon rank sum test and Tukey's test for clinicopathological response at 95% confidence interval (CI). Results: Patients in the catalpol-treated group had significantly reduced serum levels of CA 19-9 (p=0.0002, q=3.202), CEA (p=0.0002, q=3.007), MMP-2 (p <= 0.0001, q=6.883), and MMP-9 (p<0.0001, q=3.347). Only non-fatal adverse effects occurred in the catalpol treatment group (p<0.0001, q=5.375). OS and CFS were significantly increased in the catalpol treatment group compared with the placebo group (p<0.0001 q=7.586). The cost of catalpol treatment compared favorably with other treatments (p<0.0001, q=207.17). Conclusions: In this preliminary study, treatment with the Chinese herbal medicine, catalpol, showed benefits in clinical out- come, at low cost, and with no serious complications.
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