期刊
THERAPEUTIC DELIVERY
卷 3, 期 2, 页码 195-208出版社
FUTURE SCI LTD
DOI: 10.4155/TDE.11.149
关键词
Blood-brain barrier; Nasal-to-CNS drug delivery
Delivery of drug therapeutics across the blood-brain barrier is a challenging task for pharmaceutical scientists. Nasal-to-CNS drug delivery has shown promising results in preclinical efficacy models and investigatory human clinical trials. The further development of this technology with respect to the establishment of valid, predictable preclinical species models, translatable pharmacokinetic-pharmacodynamic relationships and definition of toxicology impact will help attract additional pharmaceutical investment in this drug-delivery approach. Further discoveries in nasal nanotechnology, targeted delivery devices and diagnostic olfactory imaging will serve to fuel the advancements in this area of drug delivery.
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