期刊
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
卷 27, 期 7, 页码 1815-1821出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jstrokecerebrovasdis.2018.02.028
关键词
Computed tomography; magnetic resonance imaging; cerebral atrophy; white matter lesions; validity
资金
- NRS Fellowship from the Chief Scientist Office, Scotland
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Stroke Association, UK
- Health Foundation UK
- UK MRC [G0400069]
- Efficacy, Mechanisms and Evaluation (EME) program - Medical Research Council (MRC) [EME 09-800-15]
- National Institute for Health Research (NIHR)
- Chief Scientist Office (CSO) in Scotland
- National Institute for Social Care and Health Research (NISCHR) in Wales
- Health and Social Care Research and Development (HSC R&D), Public Health Agency in Northern Ireland
- Arbetsmarknadens Partners Forsakringsbolag (AFA) Insurances Sweden
- Swedish Heart Lung Fund
- Foundation of Marianne and Marcus Wallenberg, Stockholm County Council
- Karolinska Institute Joint ALF-project grants Sweden
- Polish Ministry of Science and Education [2PO5B10928]
- Australian Heart Foundation
- Australian National Health and Medical Research Council
- Swiss National Research Foundation
- Swiss Heart Foundation
- Foundation for Health and Cardio-Neurovascular Research, Basel, Switzerland
- Assessorato alla Sanita, Regione dell'Umbria, Italy
- Danube University, Krems, Austria
- Scottish Funding Council
- CSO of the Scottish Executive
- Chest Heart and Stroke Scotland
- DesAcc
- University of Edinburgh
- Danderyd Hospital Research and Development Department
- Karolinska Institutet
- Oslo University Hospital
- Dalhousie University Internal Medicine Research Fund
- National Health Service (NHS)
- MRC [UKDRI-4002, MC_G1002455, G108/646, G0400069] Funding Source: UKRI
- Medical Research Council [G108/646, G0400069, G0700704B, MR/K026992/1, MC_G1002455] Funding Source: researchfish
Goal: Magnetic resonance imaging (MRI) is the preferred modality for research on structural age-related brain changes. However, computed tomography (CT) is widely available and has practical and cost advantages over MRI for large-scale brain imaging research studies in acutely unwell patients. However, the relationships between MRI and CT measures of white matter hyperintensities (WMH) and atrophy are unclear. We examined the relationships between visual ratings of WMH, atrophy, and old infarcts in patients who had both CT and MRI scans. Materials and Methods: Patients who had both CT and MRI scans in the International Stroke Trial-3 were studied. In both modalities, 2 raters independently completed standardized visual rating scales for WMH, and for central and superficial atrophy using a 5-point scale. In addition, 1 rater recorded old infarcts according to size and location. Findings: Seventy patients with a mean age of 69 years were studied. There were moderate to substantial intrarater CT-MRI agreements for periventricular components of WMH scales (weighted Kappa = .55-.75). Agreements for basal ganglia ratings were lower (weighted Kappa = .18-.44), partly because of the misclassification of prominent perivascular spaces. Atrophy scales showed moderate to substantial CT-MRI agreements (weighted Kappa = .44-.70). MRI was more sensitive in the detection of smaller infarcts and cavitated lesions. Conclusions: Standardized visual rating scales of white matter lesions and atrophy mostly show substantial agreement between CT and MRI. Clinical CT scans have a strong potential for wider exploitation in research studies, particularly in acutely unwell populations.
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