期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 17, 页码 2541-2546出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb01560g
关键词
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资金
- National Research Foundation of Korea (NRF) grant - Korean government (MSIP) [2012R1A3A2048814]
- Korea Health Industry Development Institute [HI15C1540]
- Innovative Medical Measurements Program from KRISS [KRISS-2017-GP2017-0020]
- Intramural Research Program of KIST
- National Natural Science Foundation of China [21376117]
- Jiangsu Natural Science Funds for Distinguished Young Scholars [BK20140043]
- Natural Science Foundation of Jiangsu Higher Education Institutions of China [14KJA150005]
Two new cyanine-based fluorescent probes 1 and 2 have been developed. Probe 1 bears two cyanine units in a single molecule, and probe 2 contains a bis(trifluoromethyl)benzenethiol moiety. Both are non-fluorescent. The addition of intracellular glutathione (GSH) significantly enhanced the NIR fluorescence of the two probes. Both probes were used to image varying amounts of GSH in living cells. In tumor bearing mice, the in vivo fluorescence intensity of both probes was higher in tumors, where GSH is overexpressed, than in normal tissues. These results suggest that these new fluorogenic probes have potential for GSH-targeting diagnostic imaging.
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