期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 30, 页码 4903-4908出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb01070f
关键词
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资金
- National Natural Science Foundation of China [21672131, 21775096, 21705102]
- Talents Support Program of Shanxi Province [2014401]
- Shanxi Province Foundation for Returnees [2017-026]
- Shanxi Province Science Foundation for Youths [201701D221061]
- Scientific Instrument Center of Shanxi University, Institute of Pharmacology and Toxicology Academy of Military Medical Sciences PLA, Peop. Rep. China [2015-12]
Hydrogen sulfide (H2S) is an endogenously produced gaseous signaling molecule with multiple functions in many physiological and pathological processes. Herein, our group developed a novel fluorescent probe (Flu-N-3) for H2S on the basis of the 7-amino-4-methylcoumarin and fluorescein FRET system. Adding H2S to a solution of Flu-N-3 resulted in a clearly observable fluorescence enhancement (50-fold). This probe showed high sensitivity and selectivity towards H2S over other reactive species with a detection limit of 0.031 mu M and a fast response time (within 8 s). Moreover, Flu-N-3 displayed little toxicity to HepG-2 cells and was successfully applied to image exogenous and endogenous H2S in living cells and nude mice.
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