期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 30, 页码 4952-4962出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb00985f
关键词
-
资金
- National Natural Science Foundation of China (NSFC) [11472032, 31470901, 51401007, 11421202]
- 111 Project [B13003]
- Foundation for the Author of National Excellent Doctoral Dissertation of PR China [201463]
Electrical stimulation (ES) and magnetic stimulation (MS) can promote bone tissue formation in vivo. Loading ES and MS simultaneously would be very beneficial for bone tissue construction in vitro or in vivo. Magnetic-conductive bi-functional scaffolds which are favorable for the transfer of ES and MS, could further facilitate bone cell/tissue growth. Poly(3,4-ethylenedioxythiophene) (PEDOT)/Fe3O4/polylactic acid-co-glycolic acid (PLGA) magnetic-conductive bi-functional fibrous scaffolds were prepared through in situ polymerization of EDOT on Fe3O4/PLGA fibers. MC3T3-E1 pre-osteoblasts were incubated on the PEDOT/Fe3O4/PLGA fibrous scaffolds and were stimulated by electrical, magnetic and electrical-magnetic signals respectively to detect the impact of different stimulation on cell viability. The measured results show that the scaffolds possess good conductivity and superparamagnetic responsiveness. Furthermore, both electrical and magnetic stimulation promoted cell proliferation and magnetic stimulation could induce cell alignment arrangement. Meanwhile, under electrical-magnetic double stimulation, cell viability was much higher than for cells under single electrical or magnetic stimulation. The growth promoting effects of PEDOT/Fe3O4 /PLGA fibrous scaffolds under electrical-magnetic double stimulation has great practical potential for bone tissue engineering.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据