期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 27, 页码 4531-4538出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb01158c
关键词
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资金
- National Basic Research Program of China (973 Program) [2015CB932200, 2012CB723402]
- National Natural Science Foundation of China [21604042, 61378081, 21574064, 61136003]
- Synergetic Innovation Center for Organic Electronics and Information Displays, Jiangsu National Synergetic Innovation Center for Advanced Materials
Hydrogen peroxide (H2O2) plays a significant role in regulating the redox balance in the living body. Compared with traditional imaging techniques, ratiometric photoacoustic imaging is no doubt a superior choice for H2O2 visualization. However, the difficult design of ratiometric probes with only one activatable agent that exhibits two changeable absorption peaks under H2O2 activation remains a big challenge. In this work, we developed a near-infrared absorbing probe, which responded to H2O2 selectively and permitted the ratiometric photoacoustic imaging of H2O2 in living mice. The probe was constructed from an Aza-BODIPY backbone attached with a benzeneboronic acid pinacol ester moiety though a quaternization reaction. Oligo(ethylene glycol) (OEG) was introduced into hydrophobic Aza-BODIPY to enhance the water-solubility of the probe. The OEG-Aza-BODIPY-BAPE probe exhibited sensitive and specific ratiometric PA signals towards H2O2. In vivo experiments also showed that the OEG-Aza-BODIPY-BAPE probe can be used for ratiometric PA imaging. Overall, our work illustrated a high sensitivity hydrophilic photoacoustic probe for ratiometric imaging of hydrogen peroxide in vitro and vivo.
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