期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 8, 页码 1279-1285出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb03012f
关键词
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资金
- National Natural Scientific Foundation of China [51573158]
- National Basic Research Program of China [2013CB834704]
- University Grants Committee of Hong Kong [AoE/P-03/08]
- Research Grants Council of Hong Kong [16301614, 16305015, C2014-15G, N_HKUST604/14]
- Guangdong Innovative Research Team Program [201101C0105067115]
- Science & Technology Plan of Shenzhen [JCYJ20160229205601482]
We report the design and synthesis of a novel cationic AIE-gen, i.e., (E)-TPEDEPy-DBz, which can be derived from a facile synthetic route. (E)-TPEDEPy-DBz is a stereo-pure isomer and shows evident AIE properties with yellow-greenish emission in the solid state (phi(F) = 43.7%). Distinct from most of the ionic AIE-gens reported in the literature, which are usually exemplified by their water solubility and the capacity for interaction with charged biological species, (E)-TPEDEPy-DBz demonstrated moderate solvatochromism and evident mechanoluminochromism behaviours. The emission of (E)-TPEDEPy-DBz can be switched between yellow-greenish in the crystalline state to red-orange in the amorphous state by grinding and fuming treatments. Due to the AIE-characteristics, cationic modification and the thus-acquired water solubility, (E)-TPEDEPy-DBz performed as a sensitive fluorescent probe to detect DNA in Tris-HCl buffer solution. More importantly, (E)-TPEDEPy-DBz showed good membrane permeability and cell viability, and the potentiality to be used as a mitochondria-specific probe working in a fluorescence turn-on mode.
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