期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 23, 页码 3946-3955出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb01122b
关键词
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资金
- National Natural Science Foundation of China [21374057, 21334004, 51673112, 21774086]
- China Postdoctoral Science Foundation [2017M623109]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- National Key Research and Development Program of China [2016YFC1100402]
Conventional antibacterial surfaces are becoming less effective due to the emergence of multidrug resistant bacteria; in addition, difficulties related to the accumulation of killed bacteria are generally encountered. To circumvent these problems, in the present work, an antibiotic-free and regenerable antibacterial hybrid film with both photothermal bactericidal activity and bacteria-releasing properties was fabricated on diverse substrates by sequential deposition of a gold nanoparticle layer (GNPL) and a phase-transitioned lysozyme film (PTLF). Due to the photothermal effect of the GNPL, the hybrid film was able to kill >99% of attached bacteria under near-infrared laser irradiation in 5 min. Moreover, the topmost PTLF layer could be degraded and detached from the surface by immersion in vitamin C solution for a short period, leading to removal of the killed bacteria and surface regeneration. The surface could be used and regenerated in this way through multiple cycles for long-term effective performance. The surface fabrication process is simple and environmentally friendly, and can be applied to diverse materials. These hybrid films thus offer a viable alternative for the killing and removal of adherent bacteria (particularly multidrug resistant bacteria) on the surfaces of medical devices for in vitro applications.
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