期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 23, 页码 3855-3858出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb00666k
关键词
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资金
- Hong Kong Baptist University [FRG2/16-17/007, FRG2/17-18/003]
- Health and Medical Research Fund [HMRF/14150561]
- Research Grants Council [HKBU/12301115]
- National Natural Science Foundation of China [21575121, 21775131, 21628502, 21502075, 21762018]
- Postdoctoral Science Foundation of Jiangxi Province [2017KY22]
- Guangdong Province Natural Science Foundation [2015A030313816]
- Hong Kong Baptist University Century Club Sponsorship Scheme 2017
- Interdisciplinary Research Matching Scheme [RC-IRMS/15-16/03, RC-IRMS/16-17/03]
- Innovation and Technology Fund [ITS/260/16FX]
- Collaborative Research Fund [C5026-16G]
- Matching Proof of Concept Fund [MPCF-001-2017/18]
- Science and Technology Development Fund, Macao SAR [098/2014/A2]
- University of Macau [MYRG2016-00151-ICMS-QRCM, MRG044/LCH/2015/ICMS]
- Natural Science Foundation of Jiangxi Province [20171BAB213008]
Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(iii) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.
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