期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 18, 页码 2778-2784出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb00372f
关键词
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资金
- NNSF of China [61525402, 61775095, 61604071]
- Jiangsu Provincial key research and development plan [BE2017741]
- Key University Science Research Project of Jiangsu Province [15KJA430006]
- Natural Science Foundation of Jiangsu Province [BK20161012]
The development of smart photosensitizers with tumor microenvironment-activable fluorescence turn-on and singlet oxygen generation plays an important role in tumor bioimaging and photodynamic therapy. Herein, a pH-activable heavy-atom-free photosensitizer (C-60-RB) has been successfully synthesized through introducing a fullerene unit onto rhodamine B hydrazide. Under acidic conditions, C-60-RB, having a spirolactam structure, can be activated to its ring-opened structure C-60-RB-H and thus, visible-light absorbance enhancement, fluorescence turn-on and triplet excited state generation can be accomplished. In the presence of hydrion, the fullerene unit in C-60-RB C-60-RB-H acting as an intramolecular spin converter can cause good intersystem crossing, and the energy gap between S-1 and T-1 (Delta E-ST) is lowered to 0.017 eV. Through encapsulation with amphiphilic DSPE-mPEG2000, water-soluble nanoparticles (NPs) of C-60-RB are obtained. In vitro experiments indicate that C-60-RB NPs are capable of universal cellular uptake and lysosomal activation (pH 4.5-5.0), and they also exhibit excellent photodynamic therapeutic effect. The fluorescence turn-on and efficient singlet oxygen generation enabled by pH-activated C-60-RB NPs testify their great potential applications for cancer diagnosis and treatment.
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