期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 5, 页码 809-815出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb03168h
关键词
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资金
- National Natural Science Foundation of China [31371009, 81671749, 81770552, 81301758]
- China Postdoctoral Science Foundation [2015M582368]
- Natural Science Foundation of Guangdong, China [2016A030313546, 2017A030313838]
- Science and Technology Planning Project of Guangdong, China [2015B020233019]
- Research Funding of Guangzhou Women and Children's Medical Center [5001-3001021, IP-2016-005]
Inflammatory bowel disease (IBD) is a group of chronic remittent or progressive inflammatory gastrointestinal tract diseases, accompanying impaired barrier function. Effective real-time monitoring of the IBD progression in time is critical to the success of bowel therapy and the improvement of patient outcomes. However, there is relatively little information regarding the detection of the intestinal barrier. In this study, we have judiciously designed and synthesized a novel D-pi-A based far-red-emissive AIE active fluorescent Probe (PTZB-FR). PTZB-FR exhibits properties suitable for in vivo imaging, such as FR emission, good photostability, large Stokes shift (similar to 184 nm), and low cytotoxicity. Moreover, confocal fluorescence microscopy and flow cytometry assay reveal the effective internalization of PTZB-FR. Most importantly, imaging living mice after oral administration of PTZB-FR confirms that fluorescence in the intestinal lumen diminishes in Dextran sulfate sodium (DSS)-induced colitis, which is attributed to disruption of intestinal barrier integrity caused by a DSS-induced colitis model, highlighting PTZB-FR as a promising reagent in the detection of intestinal barrier function during clinical examination.
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