期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 3, 页码 477-486出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb02864d
关键词
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资金
- National Natural Science Foundation of China [81430012]
- International S&T cooperation project of Shanghai S&T innovation action plan [17540712300]
Ca-Doped mesoporous SiO2 (MCS) nanoparticles with diameter of 230 nm were synthesized by a sol-gel method with some modification. As inorganic fillers, they improved the mechanical properties of the resin composites with 5%, 10%, 20% addition (5RC, 10RC, 20RC). After soaking in the simulated oral fluid (SOF), the resin composites showed excellent activity in inducing apatite-mineralization. As mesoporous nanoparticles, they can be used as carriers for loading the antibacterial drug Ciprofloxacin hydrochloride (CiH). The antibacterial testing of the resin composites with MCS-CiH (5RC-CiH, 10RC-CiH, 20RC-CiH) demonstrated excellent antibacterial effects. The incorporation of Ca-doped mesoporous SiO2 into dental resin is a suitable approach for improving the properties of the dental resin, and the MCS/resin composites have the potential for application in preventing secondary-caries.
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