期刊
ANATOMY & CELL BIOLOGY
卷 45, 期 1, 页码 17-25出版社
MEDRANG
DOI: 10.5115/acb.2012.45.1.17
关键词
NUPR1; Cholangiocarcinoma; Migration; Invasion; Proliferation
资金
- Korea Research Foundation - Korean Government (MOEHRD, Basic Research Promotion Fund) [KRF-2008-331-E00047]
- National Research Foundation of Korea [2008-331-E00047] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Nuclear protein-1 (NUPR1) is a small nuclear protein that is responsive to various stress stimuli. Although NUPR1 has been associated with cancer development, its expression and roles in cholangiocarcinoma have not yet been described. In the present study, we found that NUPR1 was over-expressed in human cholangiocarcinoma tissues, using immunohistochemistry. The role of NUPR1 in cholangiocarcinoma was examined by its specific siRNA. NUPR1 siRNA decreased proliferation, migration and invasion of human cholangiocarcinoma cell lines (HuCCT1 and SNU1196 cells). From these results, we conclude that NUPR1 is over-expressed in cholangiocarcinoma and regulates the proliferation and motility of cancer cells.
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