期刊
JOURNAL OF CANCER
卷 9, 期 13, 页码 2334-2340出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.25829
关键词
Enhancer RNAs; Enhancers; Gene transcription; Associated diseases
类别
资金
- National Key Basic Research Program of China (973 Program) [2014CB745201]
- National Natural Science Foundation of China [81772737]
- Shenzhen Municipal Government of China [JCYJ20170413161749433, JSGG20160301161836370]
- Sanming Project of Shenzhen Health and Family Planning Commission [SZSM201412018, SZSM201512037]
Enhancers are cis-acting elements that have the ability to increase the expression of target genes. Recent studies have shown that enhancers can act as transcriptional units for the production of enhancer RNAs (eRNAs), which are hallmarks of activity enhancers and are involved in the regulation of gene transcription. The in-depth study of eRNAs is of great significance for us to better understand enhancer function and transcriptional regulation in various diseases. Therefore, eRNAs may be a potential therapeutic target for diseases. Here, we review the current knowledge of the characteristics of eRNAs, the molecular mechanisms of eRNAs action, as well as diseases related to dysregulation of eRNAs.
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