期刊
JOURNAL OF CANCER
卷 9, 期 6, 页码 1078-1087出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.23596
关键词
breast cancer; SULT1E1; PPAR gamma; proliferation; invasion
类别
资金
- National Natural Science Foundation of China [NSFC.81402288]
- General Financial Grant from the China Postdoctoral Science Foundation [2016M602150]
- Natural Science Foundation of Shandong Province [ZR2017QH008]
- Shandong Province Key Research and Development Projects [2015GSF118015]
- Research Foundation for Excellent Young and Middle-aged Scientists of Shandong Province [BS2015YY028]
Sulfotransferase family 1E member 1 (SULT1E1) is known to catalyze sulfoconjugation and play a crucial role in the deactivation of estrogen homeostasis, which is involved in tumorigenesis and the progression of breast and endometrial cancers. Our previous study has shown that the protein levels of SULT1E1 were decreased in breast cancer; however, the underlying mechanism is still poorly understood. In this study, we explored the functional and molecular mechanisms by which SULT1E1 influenced breast cancer. Here, we identified that overexpression of SULT1E1 inhibited breast cancer cell growth through inducing apoptosis and arresting cell cycle progression. Furthermore, enforced expression of SULT1E1 suppressed tumor cell migration and invasion. Moreover, we found that the activation of PPAR. was required for SULT1E1-mediated downregulation of C-myc, Cyclin D1, MMP-2 and MMP-9 as well as for cell apoptosis, migration and invasion. In addition, the overexpression of SULT1E1 significantly inhibited tumor growth in vivo. Taken together, our findings indicated that SULT1E1 performed its tumor suppressor characteristics by activating PPAR., which provided a novel target for patients with breast cancer.
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