期刊
JOURNAL OF CANCER
卷 9, 期 5, 页码 767-777出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.22505
关键词
Nasopharyngeal carcinoma; exosomes; chemoradioresistance; tumor microenvironment; miRNA; non-coding RNA
类别
资金
- National Natural Science Foundation of China [81472595, 81402006]
- Research Project of Health and Family Planning Commission of Hunan Province [B20180400, B20180582]
- Development and Reform Commission of Hunan Province
Exosomes are nanosized (30-100nm) membrane microvesicles secreted through a complex cellular process. Exosomes contain a variety of bioactive molecules, such as proteins, microRNAs(miRNAs or miRs) and long non-coding RNAs (lncRNAs), playing an important role in the cell-to-cell substance transportation and signal transduction. Nasopharyngeal carcinoma-related exosomes (NPC-Exo) have been identified in circulating blood and contribute to tumor cell proliferation, angiopoiesis, and immune tolerance through remodeling of tumor microenvironment (TME). Nasopharyngeal carcinoma-related exosomes may also induce epithelial-mesenchymal transition (EMT), thus promoting tumor metastasis and chemoradioresistance. Clinically, the exosomes may serve as novel biomarkers for diagnosis and targeted therapies of nasopharyngeal carcinoma. This review article updates the understanding of exosomes in nasopharyngeal carcinoma(NPC).
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