期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 68, 期 4, 页码 193-197出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2018.1434651
关键词
Entrapment efficiency; homogeneity; ibuprofen; liposome; probe-sonication
资金
- Science and Technology Plan of Hunan Province [2015RS4002]
- Chinese Postdoctoral Scientific Research Funding [140050005]
Since probe-sonication is commonly used to homogenize liposomal formulations, it is necessary to investigate its influence on drug entrapment efficiency (EE) of liposomes. In this study, ibuprofen-loaded liposomes (IBU-Lip) dispersion was prepared from ibuprofen (IBU), soy phosphatidylcholine (SPC) and cholesterol (Chol) by thin film hydration and probe-sonication process. The influences of sonication time and power on EE were studied. Also, the effects of SPC-to-Chol ratio and drug-to-lipid ratio on EE were demonstrated. The results indicated that increasing sonication time or decreasing drug-to-lipid ratio could increase EE. Additionally, EE first increased then decreased as sonication power increased or SPC-to-Chol ratio decreased. [GRAPHICS]
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