期刊
INFECTIOUS AGENTS AND CANCER
卷 13, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13027-018-0195-4
关键词
Plasmablastic lymphoma; HIV; EBV; EPOCH; Sub-Saharan Africa
资金
- National Institutes of Health [K01TW009488, R21CA180815, U54CA190152]
- Medical Education Partnership Initiative [U2GPS001965]
- Lineberger Comprehensive Cancer Center [P30CA016086]
Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26-71), seven (58%) were male, and six (50%) were HIV-positive. Eight patients were treated with CHOP and four with a modified EPOCH regimen. One-year overall survival was 56% (95% CI 24-79%), without clear differences based on HIV status. PBL occurs in Malawi in HIV-positive and HIVnegative individuals and can be treated successfully with curative intent, even in a low-resource setting in SSA.
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