期刊
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
卷 23, 期 1, 页码 143-155出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JBHI.2018.2805773
关键词
Electrocardiography; intracavitary electrograms; atrial fibrillation; radio frequency ablation; Granger causality
类别
资金
- BBVA Foundation through I Convocatoria de Ayudas a Investigadores, Innovadores y Creadores Culturales (MG-FIAR project)
- Spanish Ministerio de Industria, Economia y Competitividad through the MIMOD-PLC [TEC2015-64835-C3-3-R]
- Comunidad de Madrid through project CASI-CAM-CM [S2013/ICE-2845]
- Spanish Ministerio de Industria, Economia y Competitividad through the ADVENTURE [TEC2015-69868-C2-1-R]
Multichannel intracavitary electrograms (EGMs) are acquired at the electrophysiology laboratory to guide radio frequency catheter ablation of patients suffering from atrial fibrillation. These EGMs are used by cardiologists to determine candidate areas for ablation (e.g., areas corresponding to high dominant frequencies or complex fractionated electrograms). In this paper, we introduce two hierarchical algorithms to retrieve the causal interactions among these multiple EGMs. Both algorithms are based on Granger causality, but other causality measures can be easily incorporated. In both cases, they start by selecting a root node, but they differ on the way in which they explore the set of signals to determine their cause-effect relationships: either testing the full set of unexplored signals (GS-CaRe) or performing a local search only among the set of neighbor EGMs (LS-CaRe). The ensuing causal model provides important information about the propagation of the electrical signals inside the atria, uncovering wavefronts and activation patterns that can guide cardiologists towards candidate areas for catheter ablation. Numerical experiments, on both synthetic signals and annotated real-world signals, show the good performance of the two proposed approaches.
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