期刊
HEART FAILURE CLINICS
卷 14, 期 1, 页码 1-+出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hfc.2017.08.001
关键词
Proenkephalin; PENK; Heart failure; Delta-opioid receptor; Enkephalin; Renal function
资金
- John and Lucille van Geest Foundation
- British Heart Foundation [FS/15/10/31223]
- British Heart Foundation [FS/12/30/29474] Funding Source: researchfish
The opioid system is activated in heart failure, which may be cardioprotective but also may be counterregulatory. Recently, systemic proenkephalin activation has been investigated in various conditions predicting mortality and kidney injury. In acute heart failure, proenkephalin independently predicts mortality and heart failure rehospitalization in addition to traditional risk markers. It also predicts worsening renal function, increasingly recognized as an important risk predictor for poor outcome in heart failure. This article explores the role of enkephalins and delta-opioid receptors in the heart, then reviews studies measuring proenkephalin levels in the circulation and their associations with prognosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据