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New Era of Studying RNA Secondary Structure and Its Influence on Gene Regulation in Plants

期刊

FRONTIERS IN PLANT SCIENCE
卷 9, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2018.00671

关键词

RNA structurome; gene regulation; regulatory RNAs; RNA structure and function; plant RNA biology

资金

  1. Biotechnology and Biological Sciences Research Council [BB/L025000/1]
  2. European Research Council (ERC) under the European Union's Horizon research and innovation program [680324]
  3. BBSRC [BBS/E/J/000C0672, BBS/E/J/000PR9788, BB/L025000/1] Funding Source: UKRI
  4. European Research Council (ERC) [680324] Funding Source: European Research Council (ERC)

向作者/读者索取更多资源

The dynamic structure of RNA plays a central role in post-transcriptional regulation of gene expression such as RNA maturation, degradation, and translation. With the rise of next-generation sequencing, the study of RNA structure has been transformed from in vitro low-throughput RNA structure probing methods to in vivo high-throughput RNA structure profiling. The development of these methods enables incremental studies on the function of RNA structure to be performed, revealing new insights of novel regulatory mechanisms of RNA structure in plants. Genome-wide scale RNA structure profiling allows us to investigate general RNA structural features over 10s of 1000s of mRNAs and to compare RNA structuromes between plant species. Here, we provide a comprehensive and up-to-date overview of: (i) RNA structure probing methods; (ii) the biological functions of RNA structure; (iii) genome-wide RNA structural features corresponding to their regulatory mechanisms; and (iv) RNA structurome evolution in plants.

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