期刊
ELIFE
卷 7, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.29915
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资金
- Canadian Institutes of Health Research [MOP93619 MOP123250]
- Natural Sciences and Engineering Research Council of Canada [262112-12]
- National Institutes of Health [R01-NS-082525, GM084491, R01-NS-035546, R01-NS-084835]
- National Natural Science Foundation of China [31671052]
- Junior Thousand Talents Program of China [0222170004]
- Wuhan Morning Light Plan of Youth Science and Technology [2017050304010295]
Cell- or network-driven oscillators underlie motor rhythmicity. The identity of C. elegans oscillators remains unknown. Through cell ablation, electrophysiology, and calcium imaging, we show: (1) forward and backward locomotion is driven by different oscillators; (2) the cholinergic and excitatory A-class motor neurons exhibit intrinsic and oscillatory activity that is sufficient to drive backward locomotion in the absence of premotor interneurons; (3) the UNC-2 P/Q/N high-voltage-activated calcium current underlies A motor neurons oscillation; (4) descending premotor interneurons AVA, via an evolutionarily conserved, mixed gap junction and chemical synapse configuration, exert state-dependent inhibition and potentiation of A motor neurons intrinsic activity to regulate backward locomotion. Thus, motor neurons themselves derive rhythms, which are dually regulated by the descending interneurons to control the reversal motor state. These and previous findings exemplify compression: essential circuit properties are conserved but executed by fewer numbers and layers of neurons in a small locomotor network.
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