期刊
CURRENT RHEUMATOLOGY REPORTS
卷 20, 期 4, 页码 -出版社
SPRINGER
DOI: 10.1007/s11926-018-0725-5
关键词
Macrophage; Leukocyte; Fibrosis; Scarring; Immunosuppression; Wound repair
类别
资金
- NHLBI NIH HHS [R01 HL141078] Funding Source: Medline
Purpose of Review Macrophages are central players in the immune response following tissue injury. These cells perform many functions, and the changing tissue microenvironment during injury shapes macrophage phenotype down a variety of polarized pathways. This review summarizes the current knowledge on the roles of macrophages during different stages of tissue injury, repair, and-if repair is not achieved-fibrosis. Recent Findings Macrophages present early in inflammation are functionally distinct from those at later stages. The predominant macrophage phenotype must transition from pro-inflammatory to pro-reparative to facilitate wound healing and scar resolution. If macrophages fail to acquire a tissue-healing phenotype, dysregulated signals can be drivers of disease processes, such as sustained, exuberant inflammation-as occurs in arthropathies-and fibrosis. Summary Comprehensive understanding of the roles of specific macrophage populations at different stages of the repair process will support the development of immune-targeted therapies for diseases such as fibrosis.
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