期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 27, 页码 14569-14572出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b04552
关键词
biosensor; conjugated polymers; fluorescence; high-throughput screening; photosensitizer
资金
- 100 Talents Program of Hebei Province, China [E2014100004]
- Program for Excellent Innovative Talents in Universities of Hebei Province, China [BJ2014011]
- Natural Science Foundation of Hebei Province [B2015202330, E2015202073]
- Tianjin Natural Science Foundation [15JCYBJC17500]
The cationic conjugated poly[3-(3'-N,N,N-triethylamino-1'-propyloxy)-4-methyl-2,5-thiophene hydrochloride] (PMNT) has been developed for high-throughput screening of photodynamic antimicrobial chemotherapy photosensitizers (PSs). The bacterial number can be detected quantitatively by PMNT via various fluorescence quenching efficiencies. The photosensitized inactivation of bacteria is not efficient with ineffective PSs, and thus the bacteria grow exponentially and can be coated tightly by PMNT through electrostatic and hydrophobic interactions, resulting in aggregates and fluorescence quenching of PMNT, whereas, conversely, effective PSs lead to original and strong fluorescence of PMNT. This new platform of high-throughput screening is promising for discovering new PSs.
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