期刊
BIOMED RESEARCH INTERNATIONAL
卷 2018, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2018/6057589
关键词
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资金
- National Natural Science Foundation of China [81600047, 81472835, 81670091]
- Natural Science Foundation of Henan Province [142300410381, 142102310409]
- Youth Key Research Program of Henan Province [154100510021]
- Natural Science Foundation of Anhui Province [1508085MH172]
- International Cooperative Project of Anhui Province [1704e1002231]
- WBE Liver Fibrosis Foundation [CFHPC20161005]
- Tianqing Liver Diseases Research Fund [TQGB20140075]
- Zhengzhou Program on Research for Public Good [163PKJHM196]
Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.
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