期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 7, 期 6, 页码 1118-1123出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201800183
关键词
C-H activation; cross-coupling; nitrogen heterocycles; radical reactions; thermal analysis
资金
- Key Science and Technology Program of Science and the Technology Department of Henan Province [152102210058, 142102210446, 132102210042]
Direct access to alkyl-substituted pyrazine N-oxides has been accomplished through an intermolecular dehydrogenative cross-coupling reaction of ethers and pyrazine N-oxides in the presence of tert-butyl hydroperoxide (TBHP). This approach successfully provided a variety of alkyl-substituted pyrazine N-oxides in up to 96% yield. Thermogravimetric analysis indicates that the degradation temperature of C2-alkyated product 3a is approximately 263 degrees C. Under pyrolysis conditions, 3a generated several compounds such as 2,5-dimethylpyrazine, 2,3,5-trimethylpyrazine, and 3-ethyl-2,5-dimethylpyrazine, which are characterized by their distinct aromas. The results of the pyrolysis experiment support the use of these compounds as possible flavor additives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据